Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum.

Davis LE, Shen JK, Cai Y.

Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.

Commercial Allium sativum (garlic) extract was given intravenously to two patients with cryptococcal meningitis and three patients with other types of meningitis. Plasma titers of anti-Cryptococcus neoformans activity rose twofold over preinfusion titers. Anti-C. neoformans activity was detected in four of five cerebrospinal fluid samples but not in pooled normal cerebrospinal fluid.
Antimicrob Agents Chemother. 1990 Apr;34(4):651-3.